Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties

Andrey E Shchekotikhin; Vladimir N Buyanov; Maria N Preobrazhenskaya

doi:10.1016/j.bmc.2004.04.042

Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties

Bioorg Med Chem. 2004 Jul 15;12(14):3923-30. doi: 10.1016/j.bmc.2004.04.042.

Authors

Andrey E Shchekotikhin¹, Vladimir N Buyanov, Maria N Preobrazhenskaya

Affiliation

¹ Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirogovskaya, 11, Moscow 119021, Russia. mnp@space.ru

PMID: 15210159
DOI: 10.1016/j.bmc.2004.04.042

Abstract

The preparation and cytotoxic properties of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione derivatives carrying N-aminoalkyl substituents are described. The N-aminobutylnaphthoindolediones obtained were studied in National Cancer Institute Screening Program and demonstrated high antiproliferative activity against 60 human cancer cell lines. All N-(4-aminobutyl) derivatives have higher potency than adriamycin or mitoxantrone against adriamycin selected multidrug resistant breast cancer cell line NCI/ADR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Cell Division / drug effects*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Naphthols / chemical synthesis*
Naphthols / pharmacology*
Spectrum Analysis

Substances

Antineoplastic Agents
Naphthols