Abstract
Various thioacetal artemisinin derivatives can inhibit the angiogenesis and might be angiogenesis inhibitors. In particular, 10 alpha-phenylthiodihydroartemisinins (5), 10 beta-benzenesulfonyl-9-epi-dihydroartemisinin (11) and 10 alpha-mercaptodihydroartemisinin (13) exhibit strong growth inhibition activity against HUVEC proliferation. Compound 11 have a good inhibitiory activity upon HUVEC tube formation, and 5 and 11 show a strong inhibitory effect on angiogenesis using CAM assay at 5 microg/egg by 90%.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals / chemistry*
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Artemisinins / chemical synthesis*
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Artemisinins / chemistry
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Artemisinins / pharmacology*
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Cell Division / drug effects
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Cell Line
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Chick Embryo
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects
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Gas Chromatography-Mass Spectrometry
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Humans
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Magnetic Resonance Spectroscopy
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology*
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Spectrophotometry, Infrared
Substances
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Acetals
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Angiogenesis Inhibitors
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Artemisinins
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Sesquiterpenes
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artemisinin