pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP

Eur J Pharm Biopharm. 2004 Jul;58(1):45-9. doi: 10.1016/j.ejpb.2004.03.013.

Abstract

The objective of this study was to obtain pH-independent release profiles from coated pellets containing drugs with pH-dependent solubility. pH-independent release of the basic model drug verapamil HCl was achieved by coating with a combination of the neutral polymer dispersions Kollicoat SR 30 D (aqueous dispersion of polyvinyl acetate) and the enteric polymer dispersion Kollicoat MAE 30 DP (aqueous dispersion of methacrylic acid and ethyl acrylate copolymer; methacrylic acid copolymer type C). The two polymers where applied either as separate layers (enteric polymer + extended release polymer or vice versa) or as a polymer blend. A careful balance of the ratios of the polymers allowed the achievement of a pH-independent release. Higher amounts of the enteric polymer in the polymer blend resulted in a reversal of the pH-dependency, e.g. a faster release at pH 6.8 than in 0.1 N HCl.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / pharmacokinetics
  • Drug Implants
  • Hydrogen-Ion Concentration
  • Polymers / chemistry
  • Polymers / pharmacokinetics
  • Polymethacrylic Acids / chemistry
  • Polymethacrylic Acids / pharmacokinetics*
  • Polyvinyls / chemistry
  • Polyvinyls / pharmacokinetics*

Substances

  • Delayed-Action Preparations
  • Drug Implants
  • Polymers
  • Polymethacrylic Acids
  • Polyvinyls
  • kollicoat MAE 30 D
  • polyvinyl acetate