Abstract
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked dementia and hypothyroidism syndrome. In addition, coregulators are thought to be closely associated with the pathogenesis of several diseases such as hormone-dependent cancers and leukemia. Based on these observations, the clinical disorders associated with some coregulator abnormalities were reviewed.
MeSH terms
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Androgen-Insensitivity Syndrome / genetics*
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Androgen-Insensitivity Syndrome / physiopathology
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Female
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Humans
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Male
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Receptors, Androgen / genetics*
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Receptors, Androgen / metabolism
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Rubinstein-Taybi Syndrome / genetics*
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Rubinstein-Taybi Syndrome / physiopathology
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Sensitivity and Specificity
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Thyroid Hormone Resistance Syndrome / genetics*
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Thyroid Hormone Resistance Syndrome / physiopathology
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Trans-Activators
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Transcriptional Activation / physiology*
Substances
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DNA-Binding Proteins
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Receptors, Androgen
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Trans-Activators