Coregulator-related diseases

Intern Med. 2004 May;43(5):368-73. doi: 10.2169/internalmedicine.43.368.

Abstract

Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked dementia and hypothyroidism syndrome. In addition, coregulators are thought to be closely associated with the pathogenesis of several diseases such as hormone-dependent cancers and leukemia. Based on these observations, the clinical disorders associated with some coregulator abnormalities were reviewed.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Androgen-Insensitivity Syndrome / genetics*
  • Androgen-Insensitivity Syndrome / physiopathology
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Female
  • Humans
  • Male
  • Receptors, Androgen / genetics*
  • Receptors, Androgen / metabolism
  • Rubinstein-Taybi Syndrome / genetics*
  • Rubinstein-Taybi Syndrome / physiopathology
  • Sensitivity and Specificity
  • Thyroid Hormone Resistance Syndrome / genetics*
  • Thyroid Hormone Resistance Syndrome / physiopathology
  • Trans-Activators
  • Transcriptional Activation / physiology*

Substances

  • DNA-Binding Proteins
  • Receptors, Androgen
  • Trans-Activators