Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat

Peptides. 2004 Jun;25(6):967-74. doi: 10.1016/j.peptides.2004.03.004.

Abstract

We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese fa/fa rats. GALP mRNA in the ARC in fa/fa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in fa/fa rats was significantly increased in 18-week-old compared to lean Fa/? rats. Insulin treatment in hyperglycemic fa/fa rats partially reversed those changes. These results suggest that the GALP gene expression in fa/fa rats might be regulated in part by leptin-independent mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arcuate Nucleus of Hypothalamus / chemistry
  • Arcuate Nucleus of Hypothalamus / metabolism*
  • Blood Glucose / analysis
  • Galanin-Like Peptide / genetics
  • Galanin-Like Peptide / metabolism*
  • Gene Expression Regulation / genetics
  • Hyperglycemia / metabolism
  • Insulin / pharmacology
  • Leptin / metabolism
  • Male
  • Neuropeptide Y / genetics
  • Neuropeptide Y / metabolism
  • Obesity / genetics
  • Obesity / metabolism*
  • Pituitary Gland, Posterior / chemistry
  • Pituitary Gland, Posterior / metabolism*
  • Pro-Opiomelanocortin / genetics
  • Pro-Opiomelanocortin / metabolism
  • RNA, Messenger / analysis
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Mutant Strains

Substances

  • Blood Glucose
  • Galanin-Like Peptide
  • Insulin
  • Leptin
  • Neuropeptide Y
  • RNA, Messenger
  • Pro-Opiomelanocortin