Abstract
10-exo-Bromoalkylidene and benzylidene deoxoartemisinin derivatives with antiangiogenic activity were synthesized from corresponding 10-alkanesulfonyl dihydroartemisinin and 10-phenylmethanesulfonyl dihydroartemisinin using a highly efficient, mild, and simple Ramberg-Bäcklund rearrangement.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkadienes / chemistry
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Alkenes / chemistry*
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / pharmacology
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Artemisinins / chemical synthesis*
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Artemisinins / pharmacology
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Cell Line
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects*
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Humans
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Inhibitory Concentration 50
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology
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Stereoisomerism
Substances
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Alkadienes
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Alkenes
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Angiogenesis Inhibitors
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Artemisinins
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Sesquiterpenes
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deoxoartemisinin