Biological evaluation of substituted quinolines

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3635-8. doi: 10.1016/j.bmcl.2004.05.026.

Abstract

Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 microM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiparasitic Agents / chemistry
  • Antiparasitic Agents / pharmacology*
  • Cell Line
  • Cell Transformation, Viral
  • Evaluation Studies as Topic
  • HTLV-I Infections
  • Leishmania / drug effects*
  • Parasitic Sensitivity Tests
  • Plasmodium falciparum / drug effects*
  • Quinolines / chemistry
  • Quinolines / pharmacology*
  • Trypanosoma / drug effects*

Substances

  • Antiparasitic Agents
  • Quinolines