Abstract
Two screening methods for the assay of amphetamines and their derivatives have been applied to the same analytical instrument for their evaluation. In addition to an assay at a cut-off of 1000 microg/l, a new specific reagent was evaluated for an ultra-sensitive assay of amphetamines and 3,4-methylendioxymetamphetamine with a cut-off of 300 microg/l. The assay confirmation was performed using high-performance liquid chromatography and gas chromatography/ mass spectrometry techniques. The results were positive for both screening methods, confirming the efficacy of two simultaneous methods with different cut-off levels.
Publication types
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Comparative Study
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Evaluation Study
MeSH terms
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3,4-Methylenedioxyamphetamine / urine
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Adolescent
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Adult
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Amphetamines / urine*
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Chromatography, High Pressure Liquid
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Clinical Chemistry Tests / methods*
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Clinical Chemistry Tests / statistics & numerical data
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Enzyme Multiplied Immunoassay Technique / statistics & numerical data
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Female
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Gas Chromatography-Mass Spectrometry
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Humans
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Immunoassay / methods*
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Immunoassay / statistics & numerical data
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Male
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Methamphetamine / urine
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Middle Aged
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N-Methyl-3,4-methylenedioxyamphetamine / urine*
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Nanostructures
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Predictive Value of Tests
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Sensitivity and Specificity
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Substance-Related Disorders / diagnosis
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Substance-Related Disorders / urine
Substances
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Amphetamines
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Methamphetamine
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3,4-Methylenedioxyamphetamine
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N-Methyl-3,4-methylenedioxyamphetamine