Synthesis of aldehydo-sugar derivatives of pyrazoloquinoline as inhibitors of herpes simplex virus type 1 replication

J Enzyme Inhib Med Chem. 2004 Feb;19(1):33-8. doi: 10.1080/14756360310001650219.

Abstract

Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.

MeSH terms

  • Aldehydes / chemistry
  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Antiviral Agents / toxicity
  • Carbohydrates / chemistry
  • Cell Line
  • Cell Survival / drug effects
  • Gentian Violet
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / metabolism
  • Mice
  • Microbial Sensitivity Tests
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Pyrazoles / toxicity
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology*
  • Quinolines / toxicity
  • Staining and Labeling
  • Structure-Activity Relationship
  • Toxicity Tests, Acute
  • Virus Replication / drug effects*

Substances

  • Aldehydes
  • Antiviral Agents
  • Carbohydrates
  • Pyrazoles
  • Quinolines
  • Gentian Violet