Abstract
Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.
MeSH terms
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Aldehydes / chemistry
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Antiviral Agents / toxicity
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Carbohydrates / chemistry
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Cell Line
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Cell Survival / drug effects
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Gentian Violet
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Herpesvirus 1, Human / drug effects*
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Herpesvirus 1, Human / metabolism
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Mice
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Microbial Sensitivity Tests
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Pyrazoles / toxicity
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Quinolines / chemical synthesis*
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Quinolines / pharmacology*
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Quinolines / toxicity
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Staining and Labeling
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Structure-Activity Relationship
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Toxicity Tests, Acute
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Virus Replication / drug effects*
Substances
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Aldehydes
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Antiviral Agents
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Carbohydrates
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Pyrazoles
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Quinolines
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Gentian Violet