Abstract
Two adjacent stereogenic centres and a pendant alkene were constructed via nucleophilic addition of a 1,3-dioxan-4-ylcopper(I) reagent to a cationic eta3-allylmolybdenum complex as part of a synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-dienoic acid, a key component of the Cryptophycins. Oxidative addition of Mo(CO)(4)(THF)(2) to allyl benzoates provides an efficient synthesis of eta3-allylmolybdenum(dicarbonyl) complexes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / chemistry
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Antineoplastic Agents / chemistry
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Cations / chemistry
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Copper / chemistry*
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Depsipeptides
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Dioxanes / chemistry*
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Esters / chemical synthesis
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Esters / chemistry
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Molecular Structure
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Molybdenum / chemistry*
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Organometallic Compounds / chemistry*
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Oxidation-Reduction
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Peptides, Cyclic / chemistry*
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Stereoisomerism
Substances
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Allyl Compounds
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Antineoplastic Agents
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Cations
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Depsipeptides
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Dioxanes
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Esters
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Organometallic Compounds
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Peptides, Cyclic
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cryptophycin
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Copper
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Molybdenum