Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

Jin Sung Kim; Hyun-Jung Lee; Myung-Eun Suh; Hea-Young Park Choo; Sang Kook Lee; Hyen Joo Park; Choonmi Kim; Sang Woo Park; Chong-Ock Lee

doi:10.1016/j.bmc.2004.04.014

Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

Bioorg Med Chem. 2004 Jul 1;12(13):3683-6. doi: 10.1016/j.bmc.2004.04.014.

Authors

Jin Sung Kim¹, Hyun-Jung Lee, Myung-Eun Suh, Hea-Young Park Choo, Sang Kook Lee, Hyen Joo Park, Choonmi Kim, Sang Woo Park, Chong-Ock Lee

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea.

PMID: 15186853
DOI: 10.1016/j.bmc.2004.04.014

Abstract

A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Humans
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Inhibitory Concentration 50
Molecular Structure
Phthalazines / chemical synthesis*
Phthalazines / chemistry
Phthalazines / toxicity*
Rhodamines / pharmacology

Substances

Imidazoles
Phthalazines
Rhodamines
lissamine rhodamine B
phthalazine