Abstract
DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.
MeSH terms
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Base Sequence / genetics
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DNA Damage*
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DNA Replication / genetics
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DNA Replication / physiology*
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DNA-Directed DNA Polymerase / genetics
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DNA-Directed DNA Polymerase / metabolism*
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Models, Molecular*
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Mutation / genetics
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Protein Conformation
Substances
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DNA-Directed DNA Polymerase