Doxifluridine-induced neurotoxicity with normal dihydropyrimidine dehydrogenase activity

Neurology. 2004 Jun 8;62(11):2136-7. doi: 10.1212/01.wnl.0000128135.46067.30.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / pharmacokinetics
  • Antimetabolites, Antineoplastic / therapeutic use
  • Biotransformation
  • Cerebellar Nuclei / drug effects*
  • Cerebellar Nuclei / pathology
  • Chemotherapy, Adjuvant / adverse effects
  • Combined Modality Therapy
  • Dihydrouracil Dehydrogenase (NADP) / blood*
  • Dysarthria / chemically induced*
  • Floxuridine / adverse effects*
  • Floxuridine / pharmacokinetics
  • Floxuridine / therapeutic use
  • Gait Disorders, Neurologic / chemically induced*
  • Gastrectomy
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Nystagmus, Pathologic / chemically induced
  • Paresthesia / chemically induced
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / surgery
  • Tremor / chemically induced

Substances

  • Antimetabolites, Antineoplastic
  • Floxuridine
  • Dihydrouracil Dehydrogenase (NADP)
  • doxifluridine