A case of Epstein-Barr Virus (EBV)-associated thymic carcinoid and investigation of existence of EBV-infected cells in thymus and thymic tumors

Hiroaki Takeuchi; Hiroshi Fujita; Fumio Iwasaki; Takako Takeuchi; Ken-Ichi Imadome; Toshika Okumiya; Tomohiro Matsui; Mutsuo Takahashi

doi:10.1128/JCM.42.6.2850-2854.2004

A case of Epstein-Barr Virus (EBV)-associated thymic carcinoid and investigation of existence of EBV-infected cells in thymus and thymic tumors

J Clin Microbiol. 2004 Jun;42(6):2850-4. doi: 10.1128/JCM.42.6.2850-2854.2004.

Authors

Hiroaki Takeuchi¹, Hiroshi Fujita, Fumio Iwasaki, Takako Takeuchi, Ken-Ichi Imadome, Toshika Okumiya, Tomohiro Matsui, Mutsuo Takahashi

Affiliation

¹ Department of Clinical Laboratory Medicine, Faculty of Medicine, Kochi University School of Medicine, Oko-cho, Nankoku, Kochi 783-8505, Japan. h.take@med.kochi-u.ac.jp

Abstract

We describe the first case of Epstein-Barr virus (EBV)-associated thymic carcinoid tumor found by in situ hybridization (ISH) on paraffin-embedded sections. ISH revealed that both tumor cells and infiltrated lymphocytes were EBV positive, while a few EBV-infected lymphocytes were detected in 2 of 11 thymuses and 1 of 11 thymomas.

Publication types

Case Reports

MeSH terms

Aged
Carcinoid Tumor / pathology
Carcinoid Tumor / virology*
Herpesvirus 4, Human / isolation & purification*
Humans
Immunohistochemistry
In Situ Hybridization
Male
Paraffin Embedding
RNA, Viral / genetics
Thymus Gland / virology*
Thymus Neoplasms / pathology
Thymus Neoplasms / virology*

Substances

Epstein-Barr virus encoded RNA 1
RNA, Viral