Combinatorial approaches to synthetic receptors

Natarajan Srinivasan; Jeremy D Kilburn

doi:10.1016/j.cbpa.2004.04.014

Combinatorial approaches to synthetic receptors

Curr Opin Chem Biol. 2004 Jun;8(3):305-10. doi: 10.1016/j.cbpa.2004.04.014.

Authors

Natarajan Srinivasan¹, Jeremy D Kilburn

Affiliation

¹ School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.

PMID: 15183329
DOI: 10.1016/j.cbpa.2004.04.014

Abstract

Combinatorial chemistry can be efficiently used for the synthesis and evaluation of binding properties of libraries of synthetic receptors. This approach has been applied particularly to 'tweezer' and other 'multi-armed' receptors, and has been used for the identification of receptors for peptides in aqueous media, and for the development of new sensors and sensor arrays.

Publication types

Review

MeSH terms

Binding Sites
Biosensing Techniques
Chemistry, Pharmaceutical
Combinatorial Chemistry Techniques*
Drug Design
Molecular Structure
Peptide Library
Peptides / chemistry
Peptides / metabolism
Receptors, Drug / analysis
Receptors, Drug / chemistry*
Receptors, Drug / metabolism

Substances

Peptide Library
Peptides
Receptors, Drug