Antiviral activity of ribosome inactivating proteins in medicine

Mini Rev Med Chem. 2004 Jun;4(5):523-43. doi: 10.2174/1389557043403800.

Abstract

Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs. Antiviral activity of RIPs is summarized here in light of their novel activities and recent developments in the field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Humans
  • Nucleic Acids / metabolism
  • Proteins / chemistry
  • Proteins / pharmacology*
  • Ribosomes / chemistry
  • Ribosomes / drug effects*
  • Ribosomes / metabolism
  • Viruses / drug effects

Substances

  • Antiviral Agents
  • Nucleic Acids
  • Proteins