Synthesis and anti-inflammatory effects of novel pimarane diterpenoid analogs

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3487-90. doi: 10.1016/j.bmcl.2004.04.054.

Abstract

Syntheses and excellent anti-inflammatory effects of a series of novel acanthoic acid analogs are reported. In particular, the mechanistic basis for their anti-inflammatory effects is also described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemical synthesis*
  • Abietanes / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Cells, Cultured
  • Cyclooxygenase Inhibitors / metabolism
  • Diterpenes / chemical synthesis*
  • Diterpenes / pharmacology
  • Edema / metabolism
  • Models, Chemical
  • Nitric Oxide / antagonists & inhibitors

Substances

  • Abietanes
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors
  • Diterpenes
  • acanthoic acid
  • pimarane
  • Nitric Oxide