Abstract
On the isolated preparations of rat aorta it was shown that the new fluoro-containing analogues of diazoxide (DiazoFp and DiazoFm) elicit vasodilatatory effects related to the activation of ATP-sensitive potassium channels. It was established that DiazoFp is a more powerful vasodilator than DiazoFm and diazoxide. It was proposed that DiazoFp action consists of two components: direct activation of sarcKATP channels and activation of sarcKATP channels, through activation of mitoKATP channels.
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Aorta / drug effects*
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Aorta / metabolism
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Diazoxide / analogs & derivatives*
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Diazoxide / pharmacology*
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Hydrocarbons, Fluorinated / pharmacology*
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In Vitro Techniques
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Potassium Channel Blockers / pharmacology
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Potassium Channels / metabolism
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Rats
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Vasodilation / drug effects*
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Vasodilator Agents / pharmacology*
Substances
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Hydrocarbons, Fluorinated
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Potassium Channel Blockers
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Potassium Channels
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Vasodilator Agents
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Adenosine Triphosphate
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Diazoxide