This study analyzes the relationships between neuroticism, extroversion, age, and sex and the intensity of perceived pain and the coping strategies used. We worked with a sample of 96 patients with chronic pain. The assessment tools were the following: the Vanderbilt Pain Management Inventory, a Spanish version of the McGill Pain Questionnaire, and the Eysenck Personality Inventory. The hypothetical model establishes positive relationships between neuroticism, the use of passive coping strategies, and the intensity of pain. On the other hand, extraversion is expected to be positively related to the use of active coping strategies and negatively related to the perceived intensity of pain. The results support the hypotheses formulated regarding the effects of the variables neuroticism and extraversion. Age is negatively related to active coping strategies and pain intensity. Men use more active strategies than women, while the latter have a greater perception of pain.