Fusion has found its calcium sensor

Nat Cell Biol. 2004 Jun;6(6):476-8. doi: 10.1038/ncb0604-476.

Abstract

Synaptic vesicle exocytosis, a finely tuned process that results in rapid neurotransmitter release, is still not fully understood. Studies in a simple reconstituted lipid bilayer system have now definitively demonstrated that synaptotagmin has a key role in calcium-mediated exocytosis and have also revealed additional aspects of exocytic fusion.

Publication types

  • News

MeSH terms

  • Animals
  • Calcium Signaling / physiology*
  • Calcium-Binding Proteins*
  • Exocytosis / physiology*
  • Humans
  • Membrane Fusion / physiology*
  • Membrane Glycoproteins / metabolism*
  • Membrane Lipids / metabolism
  • Models, Biological
  • Nerve Tissue Proteins / metabolism*
  • Synaptic Transmission / physiology
  • Synaptic Vesicles / metabolism*
  • Synaptic Vesicles / ultrastructure
  • Synaptotagmins

Substances

  • Calcium-Binding Proteins
  • Membrane Glycoproteins
  • Membrane Lipids
  • Nerve Tissue Proteins
  • Synaptotagmins