Abstract
The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Antigen-Presenting Cells / metabolism*
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Dendritic Cells / immunology*
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Humans
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Interleukin-12 / immunology
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Interleukin-12 / physiology*
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Interleukin-23
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Interleukin-23 Subunit p19
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Interleukins / immunology
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Interleukins / physiology*
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Macrophage Activation
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Macrophages / immunology*
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Signal Transduction
Substances
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IL23A protein, human
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Interleukin-23
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Interleukin-23 Subunit p19
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Interleukins
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Interleukin-12