The MPEG effect: improving asymmetric processes by simple additives

Jens Rudolph; Nina Hermanns; Carsten Bolm

doi:10.1021/jo0495079

The MPEG effect: improving asymmetric processes by simple additives

J Org Chem. 2004 May 28;69(11):3997-4000. doi: 10.1021/jo0495079.

Authors

Jens Rudolph¹, Nina Hermanns, Carsten Bolm

Affiliation

¹ Institut für Organische Chemie der RWTH Aachen, Professor Pirlet Strasse 1, D-52056 Aachen, Germany.

PMID: 15153043
DOI: 10.1021/jo0495079

Abstract

Small amounts of simple methoxy poly(ethylene glycol)s (MPEGs) have a beneficial effect on catalyzed asymmetric aryl and alkyl transfer reactions onto aldehydes. The enantiomeric excesses of the products are improved, and this "MPEG effect" allows a reduction of the catalyst loading by a factor of 10.