Abstract
A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.
MeSH terms
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Animals
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CDC2 Protein Kinase / genetics*
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Cell Cycle Proteins / genetics*
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Cyclin-Dependent Kinase Inhibitor p27
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DNA Replication / genetics*
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G2 Phase / genetics
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Humans
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Mice
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Mice, Knockout
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Mitosis / genetics*
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S-Phase Kinase-Associated Proteins / genetics
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S-Phase Kinase-Associated Proteins / metabolism*
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SKP Cullin F-Box Protein Ligases / genetics
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Tumor Suppressor Proteins / genetics*
Substances
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Cdkn1b protein, mouse
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Cell Cycle Proteins
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S-Phase Kinase-Associated Proteins
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Tumor Suppressor Proteins
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Cyclin-Dependent Kinase Inhibitor p27
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SKP Cullin F-Box Protein Ligases
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CDC2 Protein Kinase