Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis

Mol Cell. 2004 May 21;14(4):414-6. doi: 10.1016/s1097-2765(04)00268-0.

Abstract

A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.

Publication types

  • Review

MeSH terms

  • Animals
  • CDC2 Protein Kinase / genetics*
  • Cell Cycle Proteins / genetics*
  • Cyclin-Dependent Kinase Inhibitor p27
  • DNA Replication / genetics*
  • G2 Phase / genetics
  • Humans
  • Mice
  • Mice, Knockout
  • Mitosis / genetics*
  • S-Phase Kinase-Associated Proteins / genetics
  • S-Phase Kinase-Associated Proteins / metabolism*
  • SKP Cullin F-Box Protein Ligases / genetics
  • Tumor Suppressor Proteins / genetics*

Substances

  • Cdkn1b protein, mouse
  • Cell Cycle Proteins
  • S-Phase Kinase-Associated Proteins
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • SKP Cullin F-Box Protein Ligases
  • CDC2 Protein Kinase