Conservative treatment in noninvasive breast cancer

Tumori. 2004 Jan-Feb;90(1):17-21.

Abstract

Background: The elective treatment for noninvasive breast carcinoma has not yet been established. As a result of mammographic screening programs, the incidence of noninvasive tumors has increased and has lead to the same controversy already present had with invasive carcinomas: mastectomy or conserving therapy.

Methods: Since 1990, 101 patients with noninvasive breast cancer were treated with irradiation following breast-conserving surgery. All the patients had irradiation of the whole breast (mean dose, 47.6 +/- 1.2 Gy). The radiation dose boost to the tumor bed was delivered in 28.7% of the cases (mean dose, 21.03 +/- 3.06 Gy), and in 71.3%, the boost was not administered.

Results: With a median follow-up of 34 months, survival is 100%. The disease-free survival at 5 years by the Kaplan-Meier method is 93.6 +/- 8.65.

Conclusions: The conserving treatment is a valid option for treatment of patients with ductal carcinoma in situ.

MeSH terms

  • Aged
  • Breast Neoplasms / pathology
  • Breast Neoplasms / radiotherapy*
  • Breast Neoplasms / surgery*
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Carcinoma, Intraductal, Noninfiltrating / radiotherapy*
  • Carcinoma, Intraductal, Noninfiltrating / surgery*
  • Female
  • Humans
  • Mastectomy, Segmental
  • Middle Aged
  • Prospective Studies
  • Radiotherapy, Adjuvant
  • Survival Analysis
  • Treatment Outcome