Cytotoxic alkaloids from the marine sponge Thorectandra sp

Nat Prod Res. 2004 Jun;18(3):225-9. doi: 10.1080/14786410310001622077.

Abstract

Three beta-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A (2), and fascaplysin (3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 (breast) with an IC50 of 5.9 microg/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 (ovarian) human tumor cell lines with IC50s of 1.5 and 2.2 microg/mL, respectively.

MeSH terms

  • Animals
  • Breast Neoplasms / pathology
  • Cell Division / drug effects
  • Drug Screening Assays, Antitumor
  • Female
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Humans
  • Indoles / isolation & purification*
  • Indoles / pharmacology*
  • Ovarian Neoplasms / pathology
  • Porifera / chemistry*
  • Tumor Cells, Cultured

Substances

  • 1-deoxysecofascaplysin A
  • Heterocyclic Compounds, 4 or More Rings
  • Indoles
  • fascaplysine