Abstract
Three beta-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A (2), and fascaplysin (3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 (breast) with an IC50 of 5.9 microg/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 (ovarian) human tumor cell lines with IC50s of 1.5 and 2.2 microg/mL, respectively.
MeSH terms
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Animals
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Breast Neoplasms / pathology
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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Female
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Humans
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Indoles / isolation & purification*
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Indoles / pharmacology*
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Ovarian Neoplasms / pathology
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Porifera / chemistry*
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Tumor Cells, Cultured
Substances
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1-deoxysecofascaplysin A
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Heterocyclic Compounds, 4 or More Rings
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Indoles
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fascaplysine