Abstract
We analyzed cytosolic 5'-(3')-nucleotidase (dNT-1) mRNA expression by quantitative polymerase chain reaction at diagnosis in leukemic blasts from 114 patients with acute myeloid leukemia (AML) treated with ara-C. Our results show that low dNT-1 mRNA expression in leukemic blasts at diagnosis is correlated with a worse clinical outcome and suggest that this enzyme may have a role in sensitivity to ara-C in AML patients.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Antimetabolites, Antineoplastic / therapeutic use*
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Blast Crisis / enzymology*
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Cytarabine / therapeutic use*
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Humans
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Leukemia, Myeloid / drug therapy*
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Leukemia, Myeloid / pathology
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Molecular Sequence Data
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Nucleotidases / genetics
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Nucleotidases / metabolism*
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Prognosis
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RNA, Messenger / metabolism
Substances
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Antimetabolites, Antineoplastic
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RNA, Messenger
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Cytarabine
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Nucleotidases
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nucleotidase