5'-(3')-nucleotidase mRNA levels in blast cells are a prognostic factor in acute myeloid leukemia patients treated with cytarabine

Haematologica. 2004 May;89(5):617-9.

Abstract

We analyzed cytosolic 5'-(3')-nucleotidase (dNT-1) mRNA expression by quantitative polymerase chain reaction at diagnosis in leukemic blasts from 114 patients with acute myeloid leukemia (AML) treated with ara-C. Our results show that low dNT-1 mRNA expression in leukemic blasts at diagnosis is correlated with a worse clinical outcome and suggest that this enzyme may have a role in sensitivity to ara-C in AML patients.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Blast Crisis / enzymology*
  • Cytarabine / therapeutic use*
  • Humans
  • Leukemia, Myeloid / drug therapy*
  • Leukemia, Myeloid / pathology
  • Molecular Sequence Data
  • Nucleotidases / genetics
  • Nucleotidases / metabolism*
  • Prognosis
  • RNA, Messenger / metabolism

Substances

  • Antimetabolites, Antineoplastic
  • RNA, Messenger
  • Cytarabine
  • Nucleotidases
  • nucleotidase

Associated data

  • RefSeq/NP_055410