Hetero: a program to simulate the evolution of DNA on a four-taxon tree

Appl Bioinformatics. 2003;2(3):159-63.

Abstract

We present a computer program to simulate the evolution of a nucleotide sequence on a phylogenetic tree with four tips. The program, Hetero, allows users to assign lineage-specific differences in the rate matrices used to describe the evolutionary process. It has a simple user interface and output, making it equally useful in the teaching and research of phylogenetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Computer Simulation
  • DNA Mutational Analysis / methods*
  • Evolution, Molecular*
  • Gene Expression Profiling / methods*
  • Genetic Variation
  • Models, Genetic*
  • Models, Statistical
  • Molecular Biology / education
  • Monte Carlo Method
  • Phylogeny*
  • Sequence Alignment / methods*
  • Sequence Analysis, DNA / methods*
  • Teaching / methods