Abstract
We present a computer program to simulate the evolution of a nucleotide sequence on a phylogenetic tree with four tips. The program, Hetero, allows users to assign lineage-specific differences in the rate matrices used to describe the evolutionary process. It has a simple user interface and output, making it equally useful in the teaching and research of phylogenetics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Algorithms*
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Computer Simulation
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DNA Mutational Analysis / methods*
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Evolution, Molecular*
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Gene Expression Profiling / methods*
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Genetic Variation
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Models, Genetic*
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Models, Statistical
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Molecular Biology / education
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Monte Carlo Method
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Phylogeny*
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Sequence Alignment / methods*
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Sequence Analysis, DNA / methods*
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Teaching / methods