Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus

Angew Chem Int Ed Engl. 2004 May 3;43(19):2551-3. doi: 10.1002/anie.200453764.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cloning, Molecular
  • Gas Chromatography-Mass Spectrometry
  • Genes, Bacterial / genetics
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Sirolimus / analogs & derivatives
  • Sirolimus / chemistry*
  • Sirolimus / isolation & purification
  • Sirolimus / metabolism*
  • Stereoisomerism
  • Streptomyces / chemistry*
  • Streptomyces / genetics
  • Streptomyces / metabolism

Substances

  • Immunosuppressive Agents
  • pre-rapamycin
  • Sirolimus