Synthesis of OSW-1 analogs with modified side chains and their antitumor activities

Lehua Deng; Hao Wu; Biao Yu; Manrong Jiang; Jiarui Wu

doi:10.1016/j.bmcl.2004.03.081

Synthesis of OSW-1 analogs with modified side chains and their antitumor activities

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2781-5. doi: 10.1016/j.bmcl.2004.03.081.

Authors

Lehua Deng¹, Hao Wu, Biao Yu, Manrong Jiang, Jiarui Wu

Affiliation

¹ State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

PMID: 15125932
DOI: 10.1016/j.bmcl.2004.03.081

Abstract

Four analogs of OSW-1 (1-4) with modified side chains on the steroidal skeleton were synthesized following modification of our previous route for the total synthesis of OSW-1. Testing of the analogs against growth of tumor cells demonstrated that the 22-one function and the full length of the side chain of OSW-1 were not required for the antitumor action of OSW-1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Cholestenones / chemical synthesis
Cholestenones / pharmacology*
Drug Design
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Saponins / chemical synthesis
Saponins / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Cholestenones
Saponins
OSW 1