Abstract
The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25-100 microM on the growth of the transformed NIH3T3 cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / pharmacology*
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Chickens
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Choroidal Neovascularization / metabolism
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Dose-Response Relationship, Drug
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Fruit
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Gardenia*
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Iridoids / administration & dosage
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Iridoids / pharmacology*
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Iridoids / therapeutic use
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Pyrans / administration & dosage
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Pyrans / pharmacology*
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Pyrans / therapeutic use
Substances
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Angiogenesis Inhibitors
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Iridoids
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Plant Extracts
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Pyrans
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geniposide