Abstract
Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC50 values in the range 0.083 to 18.99 microM) and KB cell (in the range 3.56 to 18.22 microM) lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / administration & dosage
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Alkaloids / chemistry
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Alkaloids / pharmacology*
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Alkaloids / therapeutic use
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Line, Tumor / drug effects
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Humans
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Inhibitory Concentration 50
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KB Cells / drug effects
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Roots
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Tylophora*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Plant Extracts