Cytotoxic alkaloids from the roots of Tylophora atrofolliculata

Planta Med. 2004 May;70(5):441-5. doi: 10.1055/s-2004-818973.

Abstract

Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC50 values in the range 0.083 to 18.99 microM) and KB cell (in the range 3.56 to 18.22 microM) lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / administration & dosage
  • Alkaloids / chemistry
  • Alkaloids / pharmacology*
  • Alkaloids / therapeutic use
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line, Tumor / drug effects
  • Humans
  • Inhibitory Concentration 50
  • KB Cells / drug effects
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Roots
  • Tylophora*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts