Physical fine mapping of genes underlying X-linked deafness and non fra (X)-X-linked mental retardation at Xq21

I Bach; D Robinson; N Thomas; H H Ropers; F P Cremers

doi:10.1007/BF00221950

Physical fine mapping of genes underlying X-linked deafness and non fra (X)-X-linked mental retardation at Xq21

Hum Genet. 1992 Aug;89(6):620-4. doi: 10.1007/BF00221950.

Authors

I Bach¹, D Robinson, N Thomas, H H Ropers, F P Cremers

Affiliation

¹ Department of Human Genetics, University Hospital Nijmegen, The Netherlands.

PMID: 1511979
DOI: 10.1007/BF00221950

Abstract

Linkage studies and cytogenetically visible deletions associated with nonspecific X-linked mental retardation (XLMR) and a specific form of deafness (DFN3) have indicated that the genes responsible for these disorders are located at Xq21. Using DNA probes from this region, we have studied several overlapping deletions spanning different parts of Xq21. This has enabled us to assign the DFN3 gene and a gene for nonspecific XLMR to an interval that encompasses the locus DXS232 and that is flanked by DXS26 and DXS121.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Blotting, Southern
Child
Child, Preschool
Chromosome Mapping
Deafness / genetics*
Fragile X Syndrome
Genetic Linkage
Humans
Intellectual Disability / genetics*
X Chromosome / physiology*