Abstract
On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylonitrile / analogs & derivatives*
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Acrylonitrile / chemical synthesis*
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Acrylonitrile / chemistry
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Aminoacyltransferases / antagonists & inhibitors*
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Bacterial Proteins
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Cysteine Endopeptidases
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Kinetics
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Models, Molecular
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Structure-Activity Relationship
Substances
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Bacterial Proteins
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Aminoacyltransferases
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sortase A
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Cysteine Endopeptidases
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Acrylonitrile