Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation

Transplantation. 2004 Apr 27;77(8):1304-6. doi: 10.1097/01.tp.0000122222.93740.b2.

Abstract

Background: University of Wisconsin (UW) solution is currently the standard preservation solution used for abdominal organ transplantation. This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation.

Methods: Between October 2002 and August 2003, 20 pancreas transplants were performed. Patients were divided into two groups: UW (n=10) and HTK (n=10). Donor and recipient demographics were similar in both groups. The mean cold ischemia time for both groups was 11 +/-3 hr.

Results: There was an anticipated difference between total preservative volumes used (HTK: 4.5 +/- 1.2 L vs. UW: 3.4 +/-0.8 L; P =0.03). Patient and graft survivals to date were 100% in both groups. Serum fasting blood glucose, peak amylase, and serial amylase levels remained comparable at all intervals posttransplantation.

Conclusions: Within this range of cold ischemia time, UW and HTK demonstrate similar efficacy in pancreas preservation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adenosine
  • Adult
  • Allopurinol
  • Blood Glucose / metabolism
  • Female
  • Glucose
  • Glutathione
  • Graft Survival
  • Humans
  • Insulin
  • Male
  • Mannitol
  • Organ Preservation / methods*
  • Organ Preservation Solutions*
  • Pancreas Transplantation* / physiology
  • Pancreas*
  • Potassium Chloride
  • Procaine
  • Raffinose

Substances

  • Blood Glucose
  • Bretschneider cardioplegic solution
  • Insulin
  • Organ Preservation Solutions
  • University of Wisconsin-lactobionate solution
  • Mannitol
  • Procaine
  • Allopurinol
  • Potassium Chloride
  • Glutathione
  • Glucose
  • Adenosine
  • Raffinose