Diterpenes from the leaves of Croton zambesicus

Sebastien Block; Chiara Baccelli; Bernard Tinant; Luc Van Meervelt; Raoul Rozenberg; Jean-Louis Habib Jiwan; Gabriel Llabrès; Marie-Claire De Pauw-Gillet; Joelle Quetin-Leclercq

doi:10.1016/j.phytochem.2004.02.023

Diterpenes from the leaves of Croton zambesicus

Phytochemistry. 2004 Apr;65(8):1165-71. doi: 10.1016/j.phytochem.2004.02.023.

Authors

Sebastien Block¹, Chiara Baccelli, Bernard Tinant, Luc Van Meervelt, Raoul Rozenberg, Jean-Louis Habib Jiwan, Gabriel Llabrès, Marie-Claire De Pauw-Gillet, Joelle Quetin-Leclercq

Affiliation

¹ Laboratoire de Pharmacognosie, Unité CHAM, Université Catholique de Louvain, UCL 72.30-CHAM, Av. E. Mounier, 72, 1200 Bruxelles, Belgium.

PMID: 15110699
DOI: 10.1016/j.phytochem.2004.02.023

Abstract

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line
Croton / chemistry*
Crystallography, X-Ray
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Fibroblasts
HL-60 Cells
HeLa Cells
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry

Substances

Antineoplastic Agents, Phytogenic
Diterpenes