Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes

Aude-Emmanuelle Navarro; Nicolas Spinelli; Carole Chaix; Corinne Moustrou; Bernard Mandrand; Hugues Brisset

doi:10.1016/j.bmcl.2004.03.016

Supported synthesis of ferrocene modified oligonucleotides as new electroactive DNA probes

Bioorg Med Chem Lett. 2004 May 17;14(10):2439-41. doi: 10.1016/j.bmcl.2004.03.016.

Authors

Aude-Emmanuelle Navarro¹, Nicolas Spinelli, Carole Chaix, Corinne Moustrou, Bernard Mandrand, Hugues Brisset

Affiliation

¹ Groupe de Chimie Organique et Matériaux Moléculaires, UMR CNRS 6114, Faculté des Sciences de Luminy, case 901, 163 avenue de Luminy, 13288 Marseille Cedex 9, France.

PMID: 15109628
DOI: 10.1016/j.bmcl.2004.03.016

Abstract

The use of 1-[3-O-(2-cyanoethyl-N,N-diisopropylphosphor amidityl)propyl]ferrocene and 1-[3-O-dimethoxytrityl propyl]-1'-[3'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidityl) propyl] ferrocene as reactive synthons for DNA/RNA synthesizer allows to generate ferrocene-labelled oligonucleotides with remarkable DNA detection properties.

MeSH terms

Amino Acid Sequence
DNA Probes / chemical synthesis*
Electrochemistry
Ferrous Compounds / chemistry*
Metallocenes
Nucleic Acid Hybridization
Oligonucleotides / chemical synthesis*
Oligonucleotides / chemistry
Organophosphorus Compounds

Substances

DNA Probes
Ferrous Compounds
Metallocenes
Oligonucleotides
Organophosphorus Compounds
phosphoramidite
ferrocene