Many sources of disability impact on quality of life and some are likely to remain relatively refractory to pharmacological or surgical treatment. Rehabilitative approaches may help despite the paucity of randomized control studies. There is increasing evidence from neuroscience, reviewed here, that supports current rehabilitative approaches and most importantly, can be the basis for future rehabilitative approaches. Parkinson's disease is complex and the disabilities not absolute but relative. These disabilities can be affected by the environment or context in which the motor activities occur. These observations can be exploited and argue for the potential of rehabilitative approaches.