Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

M L Willcox; E Rakotondrazafy; R Andriamanalimanana; D Andrianasolo; P Rasoanaivo

doi:10.1016/j.trstmh.2003.10.002

Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar

Trans R Soc Trop Med Hyg. 2004 May;98(5):311-4. doi: 10.1016/j.trstmh.2003.10.002.

Authors

M L Willcox¹, E Rakotondrazafy, R Andriamanalimanana, D Andrianasolo, P Rasoanaivo

Affiliation

¹ Laboratoire de Parasitologie et Bactériologie, Service de Santé de District, Ankazobe 108, Madagascar. merlinwillcox@doctors.org.uk

PMID: 15109556
DOI: 10.1016/j.trstmh.2003.10.002

Abstract

The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Antimalarials / therapeutic use*
Child
Child, Preschool
Chloroquine / therapeutic use*
Drug Resistance
Female
Follow-Up Studies
Humans
Madagascar
Malaria / drug therapy*
Male
Middle Aged
Treatment Failure

Substances

Antimalarials
Chloroquine