[The use of the "APT test" in estimating fetal hemoglobin in genetic cordocentesis]

Ginekol Pol. 2004 Feb;75(2):119-23.
[Article in Polish]

Abstract

Objectives: To determine whether it is fetal blood and not with mother blood in question.

Design: We discuss the "Apt test" results which examines the fetal hemoglobin in blood samples obtained by genetic cordocentesis. This material was used to elaborate the fetal cariotypes.

Materials and methods: 106 samples of blood samples obtained by genetic cordocentesis were examined. Examination of each cordocentesis blood sample intended for genetic tests by means of a test estimating fetal hemoglobin (HbF). In each case the estimation was independently done by means of the Kleihauer-Betke method.

Results: The obtained results have evidenced the full usefulness of the "APT test" in genetic cordocentesis.

Conclusions: The ATP test allows to estimate the HbF in the analysed sample of fetal blood in a course of few seconds.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Cordocentesis* / instrumentation
  • Cordocentesis* / methods
  • Female
  • Fetal Blood*
  • Fetal Hemoglobin / metabolism*
  • Humans
  • Infant, Newborn
  • Maternal-Fetal Exchange*
  • Pregnancy
  • Prenatal Diagnosis / methods
  • Sensitivity and Specificity
  • Staining and Labeling

Substances

  • Fetal Hemoglobin