Abstract
We investigated the effects of a Korean traditional prescription, Geiji-Bokryung-Hwan (GBH) consisting of five herbs of Cinnamomi Ramulus (Korean name Geiji), Poria cocos (Bokryung), Moutan Cortex Radicis (Modanpi). Paeoniae Radix (Jakyak) and Persicae Semen (Doin) on tumor growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Effects of the GBH extracts on carrageenan-induced edema inflammation using female (C57BL/6XC3H) F1 (B6C3F1) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chemopreventive agent in humans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Carcinoma, Hepatocellular / enzymology
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Carcinoma, Hepatocellular / pathology
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Carrageenan / toxicity
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Cell Line, Tumor
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Cyclooxygenase 2
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Dinoprostone / metabolism
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Edema / chemically induced
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Edema / drug therapy
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Edema / pathology
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Female
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Hindlimb / drug effects
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Hindlimb / pathology
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Humans
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Hydroquinones / pharmacology
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Indomethacin / pharmacology
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Inflammation / chemically induced
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Inflammation / drug therapy*
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Inflammation / pathology
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Isoenzymes / metabolism*
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Liver Neoplasms / enzymology
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Liver Neoplasms / pathology
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Membrane Proteins
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Phenylbutazone / pharmacology
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Prostaglandin-Endoperoxide Synthases / metabolism*
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Skin Neoplasms / chemically induced
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Skin Neoplasms / pathology
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Skin Neoplasms / prevention & control
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Tetradecanoylphorbol Acetate / pharmacology
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Tyrphostins / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Geiji-Bokryung-Hwan
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Hydroquinones
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Isoenzymes
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Membrane Proteins
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Plant Extracts
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Tyrphostins
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tyrphostin AG 126
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9,10-Dimethyl-1,2-benzanthracene
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Carrageenan
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Cyclooxygenase 2
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases
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Protein-Tyrosine Kinases
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Phenylbutazone
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Dinoprostone
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Tetradecanoylphorbol Acetate
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erbstatin
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Indomethacin