Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B

Immunopharmacol Immunotoxicol. 2004 Feb;26(1):103-12. doi: 10.1081/iph-120029948.

Abstract

We investigated the effects of a Korean traditional prescription, Geiji-Bokryung-Hwan (GBH) consisting of five herbs of Cinnamomi Ramulus (Korean name Geiji), Poria cocos (Bokryung), Moutan Cortex Radicis (Modanpi). Paeoniae Radix (Jakyak) and Persicae Semen (Doin) on tumor growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Effects of the GBH extracts on carrageenan-induced edema inflammation using female (C57BL/6XC3H) F1 (B6C3F1) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chemopreventive agent in humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Carcinoma, Hepatocellular / enzymology
  • Carcinoma, Hepatocellular / pathology
  • Carrageenan / toxicity
  • Cell Line, Tumor
  • Cyclooxygenase 2
  • Dinoprostone / metabolism
  • Edema / chemically induced
  • Edema / drug therapy
  • Edema / pathology
  • Female
  • Hindlimb / drug effects
  • Hindlimb / pathology
  • Humans
  • Hydroquinones / pharmacology
  • Indomethacin / pharmacology
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Inflammation / pathology
  • Isoenzymes / metabolism*
  • Liver Neoplasms / enzymology
  • Liver Neoplasms / pathology
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Phenylbutazone / pharmacology
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / pathology
  • Skin Neoplasms / prevention & control
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tyrphostins / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Geiji-Bokryung-Hwan
  • Hydroquinones
  • Isoenzymes
  • Membrane Proteins
  • Plant Extracts
  • Tyrphostins
  • tyrphostin AG 126
  • 9,10-Dimethyl-1,2-benzanthracene
  • Carrageenan
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases
  • Protein-Tyrosine Kinases
  • Phenylbutazone
  • Dinoprostone
  • Tetradecanoylphorbol Acetate
  • erbstatin
  • Indomethacin