Abstract
The disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin were compared in rat and monkey red blood cells and liver. Our data reveal that the total ribavirin-related components (ribavirin plus its mono-, di-, and triphosphate metabolites) may account for most of the drug in monkey liver following prolonged oral administration of viramidine.
MeSH terms
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Animals
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Antiviral Agents / blood
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Antiviral Agents / pharmacokinetics*
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Area Under Curve
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Biotransformation
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Chromatography, DEAE-Cellulose
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Erythrocytes / metabolism
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Liver / metabolism*
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Macaca fascicularis
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Male
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Rats
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Rats, Sprague-Dawley
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Ribavirin / analogs & derivatives*
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Ribavirin / blood
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Ribavirin / pharmacokinetics*
Substances
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Antiviral Agents
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Ribavirin
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taribavirin