Antimicrobial chlorinated bibenzyls from the liverwort Riccardia marginata

Seung-Hwa Baek; Richard K Phipps; Nigel B Perry

doi:10.1021/np030455c

Antimicrobial chlorinated bibenzyls from the liverwort Riccardia marginata

J Nat Prod. 2004 Apr;67(4):718-20. doi: 10.1021/np030455c.

Authors

Seung-Hwa Baek¹, Richard K Phipps, Nigel B Perry

Affiliation

¹ Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 570-749, Korea.

PMID: 15104514
DOI: 10.1021/np030455c

Abstract

Three new chlorinated bibenzyls 3, 4, and 5, have been isolated from the New Zealand liverwort Riccardia marginata. This is the first report of simple chlorinated bibenzyls from any natural source. Compounds 3-5 showed antimicrobial activity against Bacillus subtilis, Candida albicans, and Trichophyton mentagrophytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Bacillus subtilis / drug effects
Bibenzyls / chemistry
Bibenzyls / isolation & purification*
Bibenzyls / pharmacology
Candida albicans / drug effects
Hydrocarbons, Chlorinated / chemistry
Hydrocarbons, Chlorinated / isolation & purification*
Hydrocarbons, Chlorinated / pharmacology
Microbial Sensitivity Tests
New Zealand
Trichophyton / drug effects

Substances

2,4,6-trichloro-3-hydroxybibenzyl
2,4-dichloro-3-hydroxybibenzyl
2-chloro-3-hydroxybibenzyl
Antifungal Agents
Bibenzyls
Hydrocarbons, Chlorinated