New diterpenes from Croton insularis

J Nat Prod. 2004 Apr;67(4):685-8. doi: 10.1021/np030423p.

Abstract

Two new diterpenes (1 and 2) have been isolated from the aerial parts of Croton insularis. Their structures have been established by NMR and mass spectral data, and the absolute configuration of 1 and related trachylobane diterpenes was determined through a series of chemical correlations.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Croton / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Leukemia L1210
  • Mice
  • Molecular Structure
  • New Caledonia
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • crotinsularin
  • ent-trachyloban-3-one