New biologically active triterpenoid saponins from Scabiosa tschiliensis

J Nat Prod. 2004 Apr;67(4):604-13. doi: 10.1021/np0304722.

Abstract

Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7, 9), hookerosides A, B (12, 13), and prosapogenin 1b all exhibited strong inhibition of pancreatic lipase in vitro.

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Lipase / antagonists & inhibitors*
  • Medicine, Chinese Traditional
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oleanolic Acid / pharmacology
  • Pancreas / enzymology
  • Plants, Medicinal / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Stereoisomerism
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Enzyme Inhibitors
  • Saponins
  • Triterpenes
  • hookeroside A
  • hookeroside B
  • Oleanolic Acid
  • Lipase