Late stent thrombosis (> 1 year) following clopidogrel withdrawal after brachytherapy treatment: need to assess aspirin resistance?

Catheter Cardiovasc Interv. 2004 May;62(1):39-42. doi: 10.1002/ccd.10756.

Abstract

We report on a patient presenting with late thrombosis of a stent 15 months after being treated with intracoronary brachytherapy. It occurred 17 days after clopidogrel withdrawal while maintaining treatment with aspirin. At the time of stent thrombosis, evaluation of platelet aggregation was performed, revealing a suboptimal response to aspirin. Pathophysiological insights of aspirin resistance and clinical implications are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angioplasty, Balloon, Coronary
  • Aspirin / therapeutic use
  • Blood Vessel Prosthesis Implantation
  • Brachytherapy*
  • Clopidogrel
  • Combined Modality Therapy
  • Coronary Angiography
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / therapy
  • Coronary Thrombosis / drug therapy*
  • Coronary Thrombosis / etiology*
  • Coronary Thrombosis / physiopathology
  • Drug Resistance / drug effects
  • Graft Occlusion, Vascular / drug therapy*
  • Graft Occlusion, Vascular / etiology*
  • Graft Occlusion, Vascular / physiopathology
  • Humans
  • Male
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Stents*
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / therapeutic use*
  • Time Factors

Substances

  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine
  • Aspirin