Neurovirulence of four encephalitogenic dengue 3 virus strains isolated in Malaysia (1992-1994) is not attributed to their envelope protein

Mun-Yik Fong; Roziyah Yusup; Rohana Yusof; Sai-Kit Lam

doi:10.1016/j.trstmh.2003.11.004

Neurovirulence of four encephalitogenic dengue 3 virus strains isolated in Malaysia (1992-1994) is not attributed to their envelope protein

Trans R Soc Trop Med Hyg. 2004 Jun;98(6):379-81. doi: 10.1016/j.trstmh.2003.11.004.

Authors

Mun-Yik Fong¹, Roziyah Yusup, Rohana Yusof, Sai-Kit Lam

Affiliation

¹ Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. fongmy@um.edu.my

PMID: 15099995
DOI: 10.1016/j.trstmh.2003.11.004

Abstract

The amino acid sequences of the envelope (E) protein of four encephalitogenic and five non-encephalitogenic dengue 3 virus strains isolated in Malaysia were determined and compared. Multiple sequence alignment revealed a high degree of similarity in the E protein of the strains suggesting that neurovirulence of these four encephalitogenic strains is not attributed to this protein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Dengue / virology*
Dengue Virus / classification
Dengue Virus / pathogenicity*
Encephalitis, Viral / virology*
Humans
Molecular Sequence Data
Viral Envelope Proteins / genetics*
Virulence

Substances

Viral Envelope Proteins

Associated data

GENBANK/AF147457
GENBANK/AF147458
GENBANK/AF147459
GENBANK/AF147460
GENBANK/AY338492
GENBANK/AY338493
GENBANK/AY338494