Abstract
The induction and maintenance of oncogenic transformation requires interference with the controls that regulate translation and transcription. The PI 3-kinase pathway, which shows gain of function in numerous and diverse human cancers, generates signals that have a positive effect on the initiation of protein synthesis. Here we review the components of the PI 3-kinase signaling pathway and the mRNA-binding protein YB-1, exploring their roles in protein synthesis and oncogenic cell transformation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Transformation, Neoplastic / metabolism*
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Humans
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PTEN Phosphohydrolase
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Phosphatidylinositol 3-Kinases / physiology
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Phosphoric Monoester Hydrolases / physiology
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Protein Biosynthesis*
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / physiology
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Proto-Oncogene Proteins c-akt
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Ribosomal Protein S6 Kinases / metabolism
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Tumor Suppressor Proteins / physiology
Substances
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Proto-Oncogene Proteins
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Tumor Suppressor Proteins
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt
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Ribosomal Protein S6 Kinases
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Phosphoric Monoester Hydrolases
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PTEN Phosphohydrolase
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PTEN protein, human