Serum prostatic-specific antigens (PSA) were found recently to be present in several female tissues and fluids. High concentrations of PSA were found in hirsute women in comparison with nonhirsute, as was found in other studies. In our study we measured the level of PSA in 20 hirsute and 10 control subjects by using an IMx machine from Abbot Laboratories (Diagnostic division, Abbot Park, Illinois 60064, USA). The age, BMI, F-G score, duration and family history of hirsutism were recorded for both groups. The results were analyzed by using SPSS. We conclude that there is no significant association between the level of PSA and the presence of hirsutism. Usage of this test as a marker of idiopathic hirsutism needs further evaluation.