Abstract
Haim-Munk and Papillon-Lefèvre are 2 closely related syndromes, inherited in an autosomal recessive pattern, manifested by palmoplantar keratoderma and early, destructive periodontitis. Recently, mutations in the cathepsin C gene have been recognized in both syndromes. We describe a patient with Haim-Munk syndrome (palmar plantar keratosis and periodontitis) and destructive arthritis of the wrists and shoulder joints, an association that has not been previously described.
MeSH terms
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arthritis / diagnostic imaging
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Arthritis / drug therapy
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Arthritis / pathology*
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Arthrography
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Female
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Fingers / diagnostic imaging
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Fingers / pathology
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Humans
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Keratoderma, Palmoplantar / pathology*
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Magnetic Resonance Imaging
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Periodontitis / pathology*
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Shoulder Joint / diagnostic imaging
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Shoulder Joint / pathology
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Syndrome
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Wrist Joint / diagnostic imaging
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Wrist Joint / pathology
Substances
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Anti-Inflammatory Agents, Non-Steroidal