Regulation of ion channel expression

Circ Res. 2004 Apr 16;94(7):874-83. doi: 10.1161/01.RES.0000124921.81025.1F.

Abstract

A potentially important mechanism controlling ion channel expression is homeostatic regulation, which can act to maintain a stable electrophysiological phenotype in cardiac myocytes as well as to provide plasticity in response to genetic, pathological, or pharmacological insults. The capabilities and limitations of the homeostatic regulatory mechanisms that contribute to the control of cardiac ion channel expression are the primary topic of this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / physiopathology
  • Feedback, Physiological
  • Forecasting
  • Gene Expression Regulation, Developmental
  • Guinea Pigs
  • Homeostasis
  • Humans
  • Ion Channels / genetics
  • Ion Channels / physiology*
  • Ion Transport / physiology*
  • Mammals / physiology
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Biological
  • Myocytes, Cardiac / metabolism*
  • Rats

Substances

  • Ion Channels